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Posted on 29 July, 2014 at 5:08
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3 Comments

Reply tcsgroupq
2:09 on 27 March, 2022 
tacrolimus, sold under the brand names protopic and prograf among others, is an immunosuppressive drug. it is used after allogeneic organ transplant to lower the risk of organ rejection, and also as a topical medication in the treatment of t-cell-mediated diseases such as eczema and psoriasis. it also used for severe refractory uveitis after bone marrow transplants, exacerbations of minimal change disease, kimura's disease, and the skin condition vitiligo, and it is used to treat dry eye syndrome in cats and dogs.

tacrolimus inhibits calcineurin, which is involved in the production of interleukin-2, a molecule that promotes the development and proliferation of t cells, as part of the body's learned (or adaptive) immune response.

chemically, it is a macrolide lactone that was first discovered in 1987, from the fermentation broth of a japanese soil sample that contained the bacterium streptomyces tsukubaensis.

medical uses
organ transplantation
it has similar immunosuppressive properties to ciclosporin, but is much more potent. immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study. clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. long-term outcome has not been improved to the same extent. tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids, mycophenolate, and il-2 receptor inhibitors such as basiliximab. dosages are titrated to target blood levels.

ulcerative colitis
in recent years,] tacrolimus has been used to suppress the inflammation associated with ulcerative colitis (uc), a form of inflammatory bowel disease. although almost exclusively used in trial cases only, tacrolimus has shown to be significantly effective in the suppression of flares of uc.

skin

tacrolimus 0.1% ointment
see also: medications used in treatment of eczema
as an ointment, tacrolimus is used in the treatment of eczema, in particular atopic dermatitis. it suppresses inflammation in a similar way to steroids, and is equally as effective as a mid-potency steroid. an important advantage of tacrolimus is that, unlike steroids, it does not cause skin thinning (atrophy), or other steroid related side effects.

it is applied on the active lesions until they heal off, but may also be used continuously in low doses (twice a week), and applied to the thinner skin over the face and eyelids.needed] clinical trials of up to one year have been conducted. recently it has also been used to treat segmental vitiligo in children, especially in areas on the face.

lupus nephritis

tacrolimus has been shown to reduce the risk of serious infection while also increasing renal remission in lupus nephritis.